Pertanyaan
Select all of the TRUE statements about the insulin receptor: A. The insulin receptor is a catalytic receptor. B. The insulin receptor dimerizes after insulin binding. C. The insulin receptor undergoes autophosphorylation on threonine residues when insulin binds to the receptor. D. The insulin receptor can activate adenylate cyclase upon insulin binding. E. The insulin receptor phosphorylates tyrosine residues on cytosolic effector proteins.
Jawaban
Penjelasan
### The insulin receptor is a type of receptor that is capable of catalyzing the phosphorylation of tyrosine residues on itself and other proteins. This is a characteristic of receptor kinases, which are a type of catalytic receptor.
## Step2: Analyze the receptor's activity upon binding to insulin
### Upon binding to insulin, the insulin receptor undergoes autophosphorylation, which is a process where it phosphorylates tyrosine residues on itself. This is not the same as the receptor phosphorylating other proteins, but it is a key step in the receptor's signaling pathway.
## Step3: Examine the receptor's role in phosphorylating effector proteins
### The insulin receptor, after being autophosphorylated, can phosphorylate tyrosine residues on cytosolic effector proteins. This is a crucial step in the signaling pathway initiated by insulin binding, leading to the activation of various downstream signaling pathways.
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