What can scientists do when they know part of a molecule is a pharmacophore?

### Scientists can tweak bits of a molecule's pharmacophore to make a drug more effective or to reduce its side effects. Examples include Noradrenaline, which expands airways and increases heart rate and blood pressure, Salbutamol, which treats asthma symptoms without raising heart rate and blood pressure, and Isoprenaline, which increases heart rate for certain heart problems.

## Step1: Understanding Pharmacophore### A pharmacophore is a part of a molecule that is responsible for its biological activity. It is the key region of a drug molecule that interacts with a receptor in the body.## Step2: Tweaking the Pharmacophore### Scientists can modify or tweak the pharmacophore of a molecule to enhance its therapeutic effects or reduce its side effects. This is done by altering the structure of the molecule in a way that changes its interaction with the receptor.## Step3: Example of Noradrenaline### Noradrenaline is an example of a molecule whose pharmacophore can be modified. It expands airways and increases heart rate and blood pressure. By tweaking its pharmacophore, scientists can create a drug that treats asthma symptoms without raising heart rate and blood pressure.## Step4: Example of Salbutamol### Salbutamol is another example of a drug whose pharmacophore has been tweaked. It treats asthma symptoms without raising heart rate and blood pressure, demonstrating the effectiveness of tweaking the pharmacophore.## Step5: Example of Isoprenaline### Isoprenaline is a drug whose pharmacophore has been modified to increase heart rate for certain heart problems. This shows how tweaking the pharmacophore can be used to treat specific conditions.