Pertanyaan
What can scientists do when they know part of a molecule is a pharmacophore?
Jawaban
Penjelasan
Step1:
Understanding Pharmacophore A pharmacophore is a part of a molecule that is responsible for its biological activity. It is the key region of a drug molecule that interacts with a receptor in the body.
Step2:
Tweaking the Pharmacophore Scientists can modify or tweak the pharmacophore of a molecule to enhance its therapeutic effects or reduce its side effects. This is done by altering the structure of the molecule in a way that changes its interaction with the receptor.
Step3:
Example of Noradrenaline Noradrenaline is an example of a molecule whose pharmacophore can be modified. It expands airways and increases heart rate and blood pressure. By tweaking its pharmacophore, scientists can create a drug that treats asthma symptoms without raising heart rate and blood pressure.
Step4:
Example of Salbutamol Salbutamol is another example of a drug whose pharmacophore has been tweaked. It treats asthma symptoms without raising heart rate and blood pressure, demonstrating the effectiveness of tweaking the pharmacophore.
Step5:
Example of IsoprenalineIsoprenaline is a drug whose pharmacophore has been modified to increase heart rate for certain heart problems. This shows how tweaking the pharmacophore can be used to treat specific conditions.
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