In terms of TRIPTANS, describe: 1) Structure 2) Mechanism of action 3) Duration of action 4) Effectivity 5) Routes and slowest to fasts 6) Relief 7) When is it most effective in terms of migraine attack

### 1) Indole derivatives with substituents on the 3rd and 5th positions 2) Selective serotonin (5-HT1) receptor agonist (specifically 5-HT1B and 5-HT1D) 3) Very short 4) Effective for ACUTE migraine 5) SC self-injection, nasal spray OR Oral (NOT IV) - SLOWEST is oral then nasal then SC 6) Relief within 2 hours for 80% of patients with migraines 7) At ANY point during the attack

## Step1: Structure of TRIPTANS### TRIPTANS are indole derivatives with substituents on the 3rd and 5th positions.## Step2: Mechanism of Action### TRIPTANS act as selective serotonin (5-HT1) receptor agonists, specifically targeting 5-HT1B and 5-HT1D receptors.## Step3: Duration of Action### TRIPTANS have a very short duration of action.## Step4: Effectivity### TRIPTANS are effective for acute migraine treatment.## Step5: Routes and Speed of Action### TRIPTANS can be administered via self-injection (SC), nasal spray, or orally (NOT intravenously). The slowest route is oral, followed by nasal spray, and then SC.## Step6: Relief Time### TRIPTANS provide relief within 2 hours for 80% of patients with migraines.## Step7: Timing of Effectiveness### TRIPTANS are most effective at any point during the migraine attack.