In terms of TRIPTANS, describe: 1) Structure 2) Mechanism of action 3) Duration of action 4) Effectivity 5) Routes and slowest to fasts 6) Relief 7) When is it most effective in terms of migraine attack

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In terms of TRIPTANS, describe: 1) Structure 2) Mechanism of action 3) Duration of action 4) Effectivity 5) Routes and slowest to fasts 6) Relief 7) When is it most effective in terms of migraine attack

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Answer 1

1) Indole derivatives with substituents on the 3rd and 5th positions 2) Selective serotonin (5-HT1) receptor agonist (specifically 5-HT1B and 5-HT1D) 3) Very short 4) Effective for ACUTE migraine 5) SC self-injection, nasal spray OR Oral (NOT IV) - SLOWEST is oral then nasal then SC 6) Relief within 2 hours for 80% of patients with migraines 7) At ANY point during the attack

Answer 2

Step1:

Structure of TRIPTANS

TRIPTANS are indole derivatives with substituents on the 3rd and 5th positions.

Step2:

Mechanism of Action

TRIPTANS act as selective serotonin (5-HT1) receptor agonists, specifically targeting 5-HT1B and 5-HT1D receptors.

Step3:

Duration of Action

TRIPTANS have a very short duration of action.

Step4:

Effectivity

TRIPTANS are effective for acute migraine treatment.

Step5:

Routes and Speed of Action

TRIPTANS can be administered via self-injection (SC), nasal spray, or orally (NOT intravenously). The slowest route is oral, followed by nasal spray, and then SC.

Step6:

Relief Time

TRIPTANS provide relief within 2 hours for 80% of patients with migraines.

Step7:

Timing of Effectiveness
TRIPTANS are most effective at any point during the migraine attack.

Pertanyaan

In terms of TRIPTANS, describe: 1) Structure 2) Mechanism of action 3) Duration of action 4) Effectivity 5) Routes and slowest to fasts 6) Relief 7) When is it most effective in terms of migraine attack

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